Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.
Hill TG. et al, (2024), Nat Metab
KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts.
Burkart M-E. et al, (2024), Brain
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life.
Vedovato N. et al, (2024), Diabetologia
KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture
Ashcroft FM., (2023), Diabetes, 72, 693 - 702
Glucokinase activity in diabetes: too much of a good thing?
Ashcroft FM. et al, (2022), Trends Endocrinol Metab
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
Haythorne E. et al, (2022), Nat Commun, 13
The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel.
Pipatpolkai T. et al, (2022), J Physiol
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate.
Koberstein JN. et al, (2022), Proc Natl Acad Sci U S A, 119
Dissection-independent production of Plasmodium sporozoites from whole mosquitoes.
Blight J. et al, (2021), Life Sci Alliance, 4
The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.
Sachse G. et al, (2021), Diabetes, 70, 1145 - 1156
Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time.
Usher SG. et al, (2021), J Vis Exp
Metabolic regulation of insulin secretion in health and disease
Haythorne E. and Ashcroft FM., (2021), Biochemist, 43, 4 - 8
Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease
Pipatpolkai T. et al, (2020), Communications Chemistry, 3
New insights into KATP channel gene mutations and neonatal diabetes mellitus.
Pipatpolkai T. et al, (2020), Nat Rev Endocrinol
Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.
Usher SG. et al, (2020), Elife, 9
Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.
Ved N. et al, (2019), Lab Anim
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Haythorne E. et al, (2019), Nat Commun, 10
Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
Cantley J. and Ashcroft FM., (2019), BMC Biol, 17